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Article

Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression.

Molecular cell - 24 Aug 2012

Chlon Timothy M, Doré Louis C, Crispino John D

Abstract excerpt

GATA-1 and its cofactor FOG-1 are required for the differentiation of erythrocytes and megakaryocytes. In contrast, mast cell development requires GATA-1 and the absence of FOG-1. Through genome-wide comparison of the chromatin occupancy of GATA-1 and a naturally occurring mutant that cannot bind FOG-1 (GATA-1(V205G)), we reveal that FOG-1 intricately regulates the chromatin occupancy of GATA-1. We identified...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22771118
DOI: 10.1016/j.molcel.2012.05.051
PMCID: PMC3432917

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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