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Article

Optogenetic control of PLC-γ1 activity directs cell motility.

The Journal of cell biology - 6 Jul 2026

Appalabhotla Ravikanth, Siesser Priscila F, Truscott Harrison, Hajicek Nicole, Sondek John, Bear James E, Haugh Jason M

Abstract excerpt

Phospholipase C-γ1 (PLC-γ1) signaling is required for mesenchymal chemotaxis, but is it sufficient to bias motility? PLC-γ1 enzyme activity is basally autoinhibited, and light-controlled membrane recruitment of wild-type PLC-γ1 (OptoPLC-γ1) in Plcg1-null fibroblasts does not trigger lipid hydrolysis, complicating efforts to isolate its contribution. Utilizing cancer-associated mutations to investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42085634
DOI: 10.1083/jcb.202507177
PMCID: PMC13225428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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