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Article

Protein kinase CK2 phosphorylates and activates p21-activated kinase 1.

Molecular biology of the cell - 1 Sept 2013

Shin Yong Jae, Kim Yong-Bae, Kim Jeong-Ho

Abstract excerpt

Activation of the p21-activated kinase 1 (PAK1) is achieved through a conformational change that converts an inactive PAK1 dimer to an active monomer. In this paper, we show that this change is necessary but not sufficient to activate PAK1 and that it is, rather, required for CK2-dependent PAK1(S223) phosphorylation that converts a monomeric PAK1 into a catalytically active form. This phosphorylation appears to...

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Source

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Identifiers

PMID: 23885116
DOI: 10.1091/mbc.E13-04-0204
PMCID: PMC3771959

Genes

PAK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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