Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Optimizing photoswitchable MEK.

Proceedings of the National Academy of Sciences of the United States of America - 17 Dec 2019

Patel Aleena L, Yeung Eyan, McGuire Sarah E, Wu Andrew Y, Toettcher Jared E, Burdine Rebecca D, Shvartsman Stanislav Y

Abstract excerpt

Optogenetic approaches are transforming quantitative studies of cell-signaling systems. A recently developed photoswitchable mitogen-activated protein kinase kinase 1 (MEK1) enzyme (psMEK) short-circuits the highly conserved Extracellular Signal-Regulated Kinase (ERK)-signaling cascade at the most proximal step of effector kinase activation. However, since this optogenetic tool relies on phosphorylation-mimicking...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinases

Share to Mutation

Share to Optogenetics

Share to Phosphorylation

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 31796593
DOI: 10.1073/pnas.1912320116
PMCID: PMC6926043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Optimizing photoswitchable MEK.PMID 31796593Read ↗

Optical control of cell signaling by single-chain photoswitchable kinases.Semantic proximity Read ↗

An optogenetic toolkit for robust activation of FGF, BMP, & Nodal signaling in zebrafishSemantic proximity Read ↗

Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway.Semantic proximity Read ↗

FRET imaging of Teen sensor captures ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitorSemantic proximity Read ↗

Assessment of the FRET-based Teen sensor to monitor ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor.Semantic proximity Read ↗

Optogenetic Signaling Activation in Zebrafish EmbryosSemantic proximity Read ↗

A transgenic zebrafish for spatiotemporal optogenetic activation of FGF/ERK signalingSemantic proximity Read ↗

Molecular mechanisms underlying cellular effects of human MEK1 mutations.Semantic proximity Read ↗

Ultrasonic Reporter of Kinase ActivitySemantic proximity Read ↗

A Real-Time Biosensor for ERK Activity Reveals Signaling Dynamics during C. elegans Cell Fate Specification.Semantic proximity Read ↗

Mimicking transient activation of protein kinases in living cells.Semantic proximity Read ↗

A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.