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Article

ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A.

Oncogene - 25 Nov 2010

Oleinik N V, Krupenko N I, Krupenko S A

Abstract excerpt

Here we report that ALDH1L1 (FDH, a folate enzyme with tumor suppressor-like properties) inhibits cell motility. The underlying mechanism involves F-actin stabilization, re-distribution of cytoplasmic actin toward strong preponderance of filamentous actin and formation of actin stress fibers. A549 cells expressing FDH showed a much slower recovery of green fluorescent protein-actin fluorescence in a fluorescence...

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Identifiers

PMID: 20729910
DOI: 10.1038/onc.2010.356
PMCID: PMC2992098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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