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Article

A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility.

The Journal of cell biology - 1 Aug 1996

Chen P, Murphy-Ullrich J E, Wells A

Abstract excerpt

Phospholipase C-gamma (PLC gamma) is required for EGF-induced motility (Chen, P., H. Xie, M.C. Sekar, K.B. Gupta, and A. Wells. J. Cell Biol. 1994. 127:847-857); however, the molecular basis of how PLC gamma modulates the actin filament network underlying cell motility remains undetermined. We propose that one connection to the actin cytoskeleton is direct hydrolysis of PIP2 with subsequent mobilization of...

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Identifiers

PMID: 8707848
DOI: 10.1083/jcb.134.3.689
PMCID: PMC2120942

Genes

EGF
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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