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Article

Oncogenic PIK3CA corrupts growth factor signaling specificity.

Molecular systems biology - 1 Feb 2025

Madsen Ralitsa R, Le Marois Alix, Mruk Oliwia N, Voliotis Margaritis, Yin Shaozhen, Sufi Jahangir, Qin Xiao, Zhao Salome J, Gorczynska Julia, Morelli Daniele, Davidson Lindsay, Sahai Erik, Korolchuk Viktor I, Tape Christopher J, Vanhaesebroeck Bart

Abstract excerpt

Technical limitations have prevented understanding of how growth factor signals are encoded in distinct activity patterns of the phosphoinositide 3-kinase (PI3K)/AKT pathway, and how this is altered by oncogenic pathway mutations. We introduce a kinetic, single-cell framework for precise calculations of PI3K-specific information transfer for different growth factors. This features live-cell imaging of PI3K/AKT...

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Share to Class I Phosphatidylinositol 3-Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Receptor, Insulin

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Source

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Identifiers

PMID: 39706867
DOI: 10.1038/s44320-024-00078-x
PMCID: PMC11791070

Genes

EGFR
IGF1
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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