Article

Cryo-EM complex structure of active GPR75 with a nanobody

2022-08-18

Abstract excerpt

Although there has been enormous progress in the last half-century in the drug discovery targeting obesity and associated co-morbidities, the clinical treatment of obesity remains tremendously challenging. GPR75 is an orphan receptor and is suggested to be a potential novel target for the control of obesity and related metabolic disorders. Inhibition of the GPR75 signaling pathway by small molecules, antibodies, o...

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Literature Corpus work: 9e554a0a-1875-573a-8c06-edbd5301f32c
DOI: 10.1101/2022.08.18.503988

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