Article

Joint Modeling of Gene-Environment Correlations and Interactions using Polygenic Risk Scores in Case-Control Studies

2023-02-15

Abstract excerpt

Polygenic risk scores (PRS) are rapidly emerging as aggregated measures of disease-risk associated with many genetic variants. Understanding the interplay of PRS with environmental factors is critical for interpreting and applying PRS in a wide variety of settings. We develop an efficient method for simultaneously modeling gene-environment correlations and interactions using PRS in case-control studies. We use a l...

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Literature Corpus work: 6296cb15-6f79-59f8-af5f-ef44af618117
DOI: 10.1101/2023.02.14.528572

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