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Comparison of Single Polygenic, Multiple Polygenic Risk, and Lifestyle for Brain Health Index in Explaining Cognitive Function Among Middle-aged and Older Adults in The Maastricht Study

2025-09-30

Abstract excerpt

<title>Abstract</title> <p>Cognitive function is shaped by both genetic and environmental factors. The Lifestyle for Brain Health (LIBRA) index, based on epidemiological evidence, targets modifiable risk and protective factors during midlife and early old age. This study compares the explanatory power of polygenic risk scores (PGSs) and the LIBRA score in relation to cognitive function among middle-aged and older...

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Literature Corpus work: f6166a40-fa58-55c0-86ba-18b5c41d846d
DOI: 10.21203/rs.3.rs-7461451/v1

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