Gene-Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood: Is APOE a Variability Gene?

doi:10.1007/s10519-015-9761-3

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Article

Gene-Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood: Is APOE a Variability Gene?

Behavior genetics - 1 Jan 2016

Reynolds Chandra A, Gatz Margaret, Christensen Kaare, Christiansen Lene, Dahl Aslan Anna K, Kaprio Jaakko, Korhonen Tellervo, Kremen William S, Krueger Robert, McGue Matt, Neiderhiser Jenae M, Pedersen Nancy L

Abstract excerpt

Despite emerging interest in gene-environment interaction (GxE) effects, there is a dearth of studies evaluating its potential relevance apart from specific hypothesized environments and biometrical variance trends. Using a monozygotic within-pair approach, we evaluated evidence of G×E for body mass index (BMI), depressive symptoms, and cognition (verbal, spatial, attention, working memory, perceptual speed) in...

Topics

Adult
Aged
Aged, 80 and over
Aging
Apolipoproteins E
Body Mass Index
Cognition
Cognition Disorders
Depression
Environment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene-Environment Interaction

Genetic Association Studies

Genetic Predisposition to Disease

Humans

Male

Middle Aged

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 26538244
DOI: 10.1007/s10519-015-9761-3
PMCID: PMC4858319

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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