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Article

Mitochondrial fusion heterogeneity drives bidirectional tumor phenotypic transition in combined hepatocellular-cholangiocarcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2026

Chen Lin, Wang Dalin, Qin Weidong, Wang Gang, Wu Dan, Li Jiaying, Wang Xingchen, Wang Yinping, Sun Xiacheng, Zhao Jing, Guo Shanshan, Ji Lele, Tian Jiming, Ding Rui, Nie Yongzhan, Xing Jinliang, Huang Qichao

Abstract excerpt

Dysregulation of mitochondrial dynamics modulates malignant cell fate; however, the substantial heterogeneity in mitochondrial dynamics among tumor cells within individual tumor nodules and the resultant functional consequences remain inadequately characterized. In this study, we induced mosaic impairment of mitochondrial fusion in mouse liver under tumorigenic conditions and unexpectedly identified the formation...

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Share to Bile Duct Neoplasms
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42048452
DOI: 10.1073/pnas.2521310123
PMCID: PMC13142996

Genes

HES1
MFN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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