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MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation

28 Aug 2025

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment that commonly support cancer development and progression. Here we show that different cancer cells transfer mitochondria to fibroblasts in cocultures and xenograft tumors, thereby inducing protumorigenic CAF features. Transplantation of functional mitochondria from cancer cells induces metabolic alterations in fibroblasts,...

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PMID: 40877413
DOI: 10.1038/s43018-025-01038-6

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