Article
The Co-mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion-Driven Cholangiocarcinoma.
Hepatology (Baltimore, Md.) - 1 Sept 2021
Kendre Gajanan, Marhenke Silke, Lorz Georgina, Becker Diana, Reineke-Plaaß Tanja, Poth Tanja, Murugesan Karthikeyan, Kühnel Florian, Woller Norman, Wirtz Ralph M, Pich Andreas, Marquardt Jens U, Saborowski Michael, Vogel Arndt, Saborowski Anna
Abstract excerpt
BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and a highly lethal malignancy. Chemotherapeutic options are limited, but a considerable subset of patients harbors genetic lesions for which targeted agents exist. Fibroblast growth factor receptor 2 (FGFR2) fusions belong to the most frequent and therapeutically relevant alterations in ICC, and the first...
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