Article

Mitochondrial Fusion Suppresses Pancreatic Cancer Growth via Reduced Oxidative Metabolism

2018-03-11

Abstract excerpt

<h4>Summary</h4> Pancreatic cancer is a highly lethal disease whose aggressive biology that is driven by mitochondrial oxidative metabolism. Mitochondria normally form a network of fused organelles, but we find that patient-derived and genetically engineered murine pancreatic cancer cells exhibit highly fragmented mitochondria with robust oxygen consumption rates (OCR). When mitochondrial fusion was activated by...

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Literature Corpus work: 73e265ad-3aca-571a-bbae-97961dfcf3c4
DOI: 10.1101/279745

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