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A functional study of all 40 Caenorhabditis elegans insulin-like peptides

11 Sept 2018

Abstract excerpt

The human genome encodes 10 insulin-like genes, whereas the Caenorhabditis elegans genome remarkably encodes 40 insulin-like genes. Knockout strategies to determine the roles of all the insulin/insulin-like peptide ligands (INS) in C. elegans has been challenging due to functional redundancy. Here, we individually overexpressed each of the 40 ins genes pan-neuronally, and monitored multiple phenotypes including:...

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PMID: 30206121
DOI: 10.1074/jbc.ra118.004542

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