Article

A functional study of all 40 <i>C. elegans</i> insulin-like peptides

2018-06-01

Abstract excerpt

The human genome encodes ten insulin-like genes, whereas the C. elegans genome remarkably encodes forty insulin-like genes. The roles of insulin/insulin-like peptide ligands (INS) in C. elegans are not well understood. The functional redundancy of the forty INS genes makes it challenging to address their functions by using knock out strategies. Here, we individually overexpressed each of the forty ins genes pan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e039e685-09ae-5ed5-b430-c5dbb92f5aa0
DOI: 10.1101/336750

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A functional study of all 40 <i>C. elegans</i> insulin-like peptidesDOI 10.1101/336750Read

A functional study of all 40 Caenorhabditis elegans insulin-like peptidesSemantic proximity Read

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.Semantic proximity Read

Drosophila insulin‐like peptides: from expression to functions – a reviewSemantic proximity Read

Role of insulin/insulin-like growth factor 1 signaling pathway in longevitySemantic proximity Read

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans.Semantic proximity Read

Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegansSemantic proximity Read

daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.Semantic proximity Read

Disruption of ins-11, a Caenorhabditis elegans insulin-like gene, and phenotypic analyses of the gene-disrupted animal.Semantic proximity Read

INS-17 acts as a nutrient deprivation signal to mediate adult IIS-regulated associative behaviors in C. elegans.Semantic proximity Read

Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs.Semantic proximity Read

An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.Semantic proximity Read

NeuropeptidesSemantic proximity Read