Article
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
Genes & development - 15 Mar 2001
Pierce S B, Costa M, Wisotzkey R, Devadhar S, Homburger S A, Buchman A R, Ferguson K C, Heller J, Platt D M, Pasquinelli A A, Liu L X, Doberstein S K, Ruvkun G
Abstract excerpt
The activity of the DAF-2 insulin-like receptor is required for Caenorhabditis elegans reproductive growth and normal adult life span. Informatic analysis identified 37 C. elegans genes predicted to encode insulin-like peptides. Many of these genes are divergent insulin superfamily members, and many are clustered, indicating recent diversification of the family. The ins genes are primarily expressed in neurons,...
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