Article
Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans.
Neuron - 6 Feb 2013
Chen Zhunan, Hendricks Michael, Cornils Astrid, Maier Wolfgang, Alcedo Joy, Zhang Yun
Abstract excerpt
The insulin/insulin-like peptides (ILPs) regulate key events in physiology, including neural plasticity. However, the cellular and circuit mechanisms whereby ILPs regulate learning remain largely unknown. Here, we characterize two ILPs that play antagonistic roles in aversive olfactory learning of C. elegans. We show that the ILP ins-6 acts from ASI sensory neurons to enable learning by repressing the...
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