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Article

Multiomic Single-Cell Sequencing Identifies BCR::ABL1 as an Acquired Resistance Mechanism in FLT3+ AML.

European journal of haematology - 1 Aug 2026

Kennedy Vanessa E, Peretz Cheryl A C, Koh Andrew, Tran Elaine, Dhingra Dalia, Gulati Saurabh, Sciambi Adam, Sala-Torra Olga, Beppu Lan, Radich Jerald P, Smith Catherine C

Abstract excerpt

BCR::ABL1 acquisition is an emerging but poorly characterized resistance mechanism in FLT3-mutated AML. Using multiomic single-cell DNA sequencing, we characterized clonal evolution in a patient with FLT3-ITD AML who acquired BCR::ABL1 with FLT3 inhibitor resistance. Phylogenetic reconstruction confirmed BCR::ABL1 as a branch event co-occurring with FLT3-ITD and restricted to specific blast populations,...

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Topics

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Share to Drug Resistance, Neoplasm
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusion Proteins, bcr-abl

Share to Leukemia, Myeloid, Acute

Share to Multiomics

Share to Protein Kinase Inhibitors

Share to Single-Cell Analysis

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Source

Identifiers

PMID: 42046307
DOI: 10.1111/ejh.70207

Genes

ABL1
BCR
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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