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Article

Detection of BCR-ABL1 mutations in chronic myeloid leukaemia by massive parallel sequencing.

British journal of haematology - 1 Feb 2013

Eyal Eran, Tohami Tali, Amir Amnon, Cesarkas Karen, Jacob-Hirsch Jasmine, Volchek Yuliya, Nagler Arnon, Rechavi Gideon, Amariglio Ninette

Abstract excerpt

The ability to sequence nucleic acids at an unprecedented pace and decreased costs using massive parallel sequencing (MPS) strongly affects biomedical research. Here we applied MPS for the detection of rare, clinically relevant mutations in a chronic myeloid leukaemia (CML) patient. Tyrosine kinase inhibitors revolutionized CML therapy but in some patients the disease progresses due to resistance-conferring...

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Share to DNA Mutational Analysis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusion Proteins, bcr-abl

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Share to High-Throughput Nucleotide Sequencing

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 23252482
DOI: 10.1111/bjh.12171

Genes

ABL1
BCR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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