Article
Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia.
Nature - 1 Apr 2025
Kamizela Aleksandra E, Leongamornlert Daniel, Williams Nicholas, Wang Xin, Nyamondo Kudzai, Dawson Kevin, Spencer Chapman Michael, Guo Jing, Lee Joe, Mane Karim, Milne Kate, Green Anthony R, Chevassut Timothy, Campbell Peter J, Ellinor Patrick T, Huntly Brian J P, Baxter E Joanna, Nangalia Jyoti
Abstract excerpt
Mutation of some genes drives uncontrolled cell proliferation and cancer. The Philadelphia chromosome in chronic myeloid leukaemia (CML) provided the very first such genetic link to cancer1,2. However, little is known about the trajectory to CML, the rate of BCR::ABL1 clonal expansion and how this affects disease. Using whole-genome sequencing of 1,013 haematopoietic colonies from nine patients with CML aged 22...
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