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Article

Instability in Pentanucleotide Markers in a Subset of Microsatellite Instability-High Colorectal Cancer.

Current oncology (Toronto, Ont.) - 2 Apr 2026

Yilmaz Ahmet, Frankel Wendy L, Swanson Benjamin J, Miller Kristin, Bacher Jason, Bigley Christopher, Nelsen Lori, Kalady Matthew F, Coleman Joshua F, Pearlman Rachel, Hampel Heather

Abstract excerpt

Microsatellite instability (MSI) testing is frequently used to screen patients for the early detection of Lynch syndrome, the most common hereditary colorectal cancer syndrome. MSI testing compares microsatellite repeat lengths in tumor DNA with those in matched normal tissue from the same patient. Therefore, precise sample identification is critical for obtaining reliable test results. The Penta-C and Penta-D...

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PMID: 42041724
DOI: 10.3390/curroncol33040205
PMCID: PMC13114762

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