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Article

Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors.

Journal of translational medicine - 12 Jan 2018

Takehara Yuko, Nagasaka Takeshi, Nyuya Akihiro, Haruma Tomoko, Haraga Junko, Mori Yoshiko, Nakamura Keiichiro, Fujiwara Toshiyoshi, Boland C Richard, Goel Ajay

Abstract excerpt

BACKGROUND: To screen tumors with microsatellite instability (MSI) arising due to DNA mismatch repair deficiency (dMMR), a panel of five quasi-monomorphic mononucleotide-repeat markers amplified in a multiplex PCR (Pentaplex) are commonly used. In spite of its several strengths, the pentaplex assay is not robust at detecting the loss of MSH6-deficiency (dMSH6). In order to overcome this challenge, we designed...

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Biomarkers, Tumor
Colorectal Neoplasms
DNA
DNA Mismatch Repair
Germ Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Repeats

Reproducibility of Results

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Open in PubMed Open full text

Identifiers

PMID: 29329588
DOI: 10.1186/s12967-017-1376-4
PMCID: PMC5767035

Genes

MSH6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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