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Article

A genome-wide view of microsatellite instability: old stories of cancer mutations revisited with new sequencing technologies.

Cancer research - 15 Nov 2014

Kim Tae-Min, Park Peter J

Abstract excerpt

Microsatellites are simple tandem repeats that are present at millions of loci in the human genome. Microsatellite instability (MSI) refers to DNA slippage events on microsatellites that occur frequently in cancer genomes when there is a defect in the DNA-mismatch repair system. These somatic mutations can result in inactivation of tumor-suppressor genes or disrupt other noncoding regulatory sequences, thereby...

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Identifiers

PMID: 25371413
DOI: 10.1158/0008-5472.CAN-14-1225
PMCID: PMC4233171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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