Article
An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers.
PloS one - 24 Feb 2010
Goel Ajay, Nagasaka Takeshi, Hamelin Richard, Boland C Richard
Abstract excerpt
PURPOSE: Microsatellite instability (MSI) is used to screen colorectal cancers (CRC) for Lynch Syndrome, and to predict outcome and response to treatment. The current technique for measuring MSI requires DNA from normal and neoplastic tissues, and fails to identify tumors with specific DNA mismatch repair (MMR) defects. We tested a panel of five quasi-monomorphic mononucleotide repeat markers amplified in a...
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