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Article

An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers.

PloS one - 24 Feb 2010

Goel Ajay, Nagasaka Takeshi, Hamelin Richard, Boland C Richard

Abstract excerpt

PURPOSE: Microsatellite instability (MSI) is used to screen colorectal cancers (CRC) for Lynch Syndrome, and to predict outcome and response to treatment. The current technique for measuring MSI requires DNA from normal and neoplastic tissues, and fails to identify tumors with specific DNA mismatch repair (MMR) defects. We tested a panel of five quasi-monomorphic mononucleotide repeat markers amplified in a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20195377
DOI: 10.1371/journal.pone.0009393
PMCID: PMC2827558

Genes

MSH6
MLH1
MSH2
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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