Article
Mononucleotide repeats BAT-26 and BAT-25 accurately detect MSI-H tumors and predict tumor content: implications for population screening.
International journal of cancer - 20 Jan 2005
Brennetot Caroline, Buhard Olivier, Jourdan Florence, Flejou Jean-François, Duval Alex, Hamelin Richard
Abstract excerpt
Tumors with a defective DNA mismatch repair system (MSI-H tumors) have distinct molecular and clinicopathologic profiles compared with mismatch repair-proficient tumors and are associated with a relatively favorable prognosis. There is evidence to suggest that colorectal cancer patients with MSI-H tumors respond differently to adjuvant chemotherapy. Determination of MSI status also has clinical application for...
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