Variant-to-Biomarker Integration and Mechanistic Validation Identify CES1 as a Copy Number-Linked Predictor of Radiotherapy Response in Rectal Cancer.

Abstract excerpt

Background: Radiotherapy is a fundamental component of rectal cancer treatment, yet patient responses remain highly heterogeneous due to the lack of reliable biomarkers supported by genomic variation evidence. Integrating multi-cohort transcriptomic data with machine-learning approaches enables systematic identification of genes with both predictive and therapeutic relevance. This study aimed to develop a robust...

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