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Leveraging a Patient-Derived Tumoroid Platform for Precision Radiotherapy: Uncovering DNA Damage Repair Inhibitor-Mediated Radiosensitization and Therapeutic Resistance in Rectal Cancer

2025-01-16

Abstract excerpt

<h4>Background</h4> Precision radiation strategies that expand the therapeutic window by selectively sensitizing tumors and sparing normal tissues are needed. We developed a matched tumoroid-organoid preclinical platform to identify and characterize personalized radiosensitization strategies. <h4>Methods</h4> We established 15 rectal cancer-derived tumoroids and 3 matched normal rectal epithelial organoids. Whole...

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Literature Corpus work
88c98a84-916b-5aec-a566-570dda0d39f4
DOI
10.1101/2025.01.15.25320629
Open publication

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Leveraging a Patient-Derived Tumoroid Platform for Precision Radiotherapy: Uncovering DNA Damage Repair Inhibitor-Mediated Radiosensitization and Therapeutic Resistance in Rectal CancerDOI 10.1101/2025.01.15.25320629
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