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Article

Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer.

International journal of cancer - 1 Jul 2024

Hammarström Klara, Nunes Luís, Mathot Lucy, Mezheyeuski Artur, Lundin Emma, Korsavidou Hult Nafsika, Imam Israa, Osterlund Emerik, Sjöblom Tobias, Glimelius Bengt

Abstract excerpt

Rectal cancer poses challenges in preoperative treatment response, with up to 30% achieving a complete response (CR). Personalized treatment relies on accurate identification of responders at diagnosis. This study aimed to unravel CR determinants, overall survival (OS), and time to recurrence (TTR) using clinical and targeted sequencing data. Analyzing 402 patients undergoing preoperative treatment, tumor stage,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoadjuvant Therapy

Share to Neoplasm Recurrence, Local

Share to Nerve Tissue Proteins

Share to Proto-Oncogene Proteins p21(ras)

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Source

Identifiers

PMID: 38376070
DOI: 10.1002/ijc.34880

Genes

TTR
BRAF
KRAS
SMAD4
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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