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Article

A genetic basis for the variation in the vulnerability of cancer to DNA damage

25 Apr 2016

Abstract excerpt

Radiotherapy is not currently informed by the genetic composition of an individual patient's tumour. To identify genetic features regulating survival after DNA damage, here we conduct large-scale profiling of cellular survival after exposure to radiation in a diverse collection of 533 genetically annotated human tumour cell lines. We show that sensitivity to radiation is characterized by significant variation...

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PMID: 27109210
DOI: 10.1038/ncomms11428

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