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Article

KRASG12V/A146T mutations are associated with nCRT resistance via enhanced DNA double-strand break repair and support a deep learning prediction framework in LARC.

Cellular & molecular biology letters - 28 May 2026

Liu Hengchang, Bu Dechao, Yu Guanhua, Wei Ran, Jin Hui, Liu Yixiao, Guan Xu, Zhao Zhixun, Chen Haipeng, Zhao Yi, Jiang Zheng

Abstract excerpt

BACKGROUND: Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer (LARC), yet clinically validated biomarkers for predicting response remain lacking. This study aimed to identify candidate molecular events associated with nCRT response and to develop a pretreatment prediction framework integrating genomic and pathological information. METHODS: Whole-exome sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42210090
DOI: 10.1186/s11658-026-00947-3
PMCID: PMC13397665

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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