Integrative bulk and single-cell transcriptomics identify a recurrence-prognostic risk model with exploratory associations with treatment-response phenotypes in colorectal cancer.

Abstract excerpt

Chemoresistance remains a major obstacle to improving outcomes in colorectal cancer (CRC), particularly among patients receiving 5-fluorouracil (5-FU)-based therapy. Here, we developed a READ-derived response-associated gene signature for recurrence stratification and performed exploratory cross-cohort evaluation in additional colorectal cancer cohorts, while further exploring its association with...

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