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Article

Identification of PSMA4 as a Therapeutic Target for Atherosclerosis: A Comprehensive Multiomics Mendelian Randomization Analysis.

Annals of human genetics - 1 Jul 2026

Yu Yongchao, Zhu Yuan, Tian Qian, Shao Lijuan, Zeng Jiao, Xu Dandan, Mo Xiangang

Abstract excerpt

PURPOSE: Atherosclerosis (AS) is a leading cause of cardiovascular disease, and current treatments often fail to induce plaque regression. This study aims to identify novel, genetically supported therapeutic targets for AS to enable more effective drug development. METHODS: We employed an integrative multiomics framework, primarily using summary-data-based Mendelian randomization (SMR) to assess causal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42032825
DOI: 10.1111/ahg.70039

Genes

PSMA4

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