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Integrative genomic and proteomic analyses identify candidate genetic loci and genetically supported proteins in age-related macular degeneration

14 Aug 2026

Abstract excerpt

BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of visual impairment; however, robust drug targets for primary prevention remain elusive. This study aimed to identify candidate genetic loci and putative genetically supported proteins for AMD through integrative genomics and proteomics. METHODS: A genome-wide association study (GWAS) meta-analysis (28,543 cases and 1,072,092 controls) was...

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PMID: 42601635
DOI: 10.1186/s40662-026-00502-3

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