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Article

PE/PPE proteins contribute to Mycobacterium tuberculosis drug resistance.

Nature communications - 24 Apr 2026

Boradia Vishant, Chen Junxi, Frando Andrew, Clark Lindsay V, Grundner Christoph

Abstract excerpt

The mycobacterial outer membrane (OM) creates a formidable permeability barrier, and whether drugs traverse it by mechanisms other than passive diffusion remains unclear. The proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) proteins of pathogenic mycobacteria include several OM transporters. Because bacterial transporters are also major contributors to drug resistance, we tested the role of...

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Identifiers

PMID: 42031738
DOI: 10.1038/s41467-026-72431-7
PMCID: PMC13315784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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