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PPE38 Modulates the Innate Immune Response and Is Required for Mycobacterium marinum Virulence

29 Oct 2011

Abstract excerpt

The proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) family proteins are prevalent in pathogenic mycobacteria and play a diverse role in mycobacterial pathogenesis. While some members have been studied, the function of most PE/PPE proteins remains unknown. In this study, we isolated a transposon-inactivated PPE38 mutant of Mycobacterium marinum and characterized its phenotype. We found that the...

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PMID: 22038915
DOI: 10.1128/iai.05249-11

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