Article
Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis.
Nature microbiology - 1 Feb 2018
Ates Louis S, Dippenaar Anzaan, Ummels Roy, Piersma Sander R, van der Woude Aniek D, van der Kuij Kim, Le Chevalier Fabien, Mata-Espinosa Dulce, Barrios-Payán Jorge, Marquina-Castillo Brenda, Guapillo Carolina, Jiménez Connie R, Pain Arnab, Houben Edith N G, Warren Robin M, Brosch Roland, Hernández-Pando Rogelio, Bitter Wilbert
Abstract excerpt
Mycobacterium tuberculosis requires a large number of secreted and exported proteins for its virulence, immune modulation and nutrient uptake. Most of these proteins are transported by the different type VII secretion systems1,2. The most recently evolved type VII secretion system, ESX-5, secretes dozens of substrates belonging to the PE and PPE families, which are named for conserved proline and glutamic acid...
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