Article

PE/PPE proteins contribute to <i>Mycobacterium tuberculosis</i> drug resistance

2025-09-24

Abstract excerpt

<h4>ABSTRACT</h4> The outer membrane (OM) of mycobacteria is a formidable permeability barrier that confers drug tolerance, and whether drugs traverse the OM by mechanisms beyond passive diffusion remains unclear. The proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) proteins of pathogenic mycobacteria include several OM transporters. Here, we tested the role of PE/PPE proteins in Mycobacterium...

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Literature Corpus work: e7fd4bcb-5353-577f-b722-70411ef9d3b9
DOI: 10.1101/2025.09.24.678375

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