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Article

PPE51 mediates uptake of trehalose across the mycomembrane of Mycobacterium tuberculosis.

Scientific reports - 8 Feb 2022

Babu Sait Mohammed Rizwan, Koliwer-Brandl Hendrik, Stewart Jessica A, Swarts Benjamin M, Jacobsen Marc, Ioerger Thomas R, Kalscheuer Rainer

Abstract excerpt

The disaccharide trehalose is essential for viability of Mycobacterium tuberculosis, which synthesizes trehalose de novo but can also utilize exogenous trehalose. The mycobacterial cell wall encompasses two permeability barriers, the cytoplasmic membrane and the outer mycolic acid-containing mycomembrane. The ABC transporter LpqY-SugA-SugB-SugC has previously been demonstrated to mediate the specific uptake of...

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PMID: 35136132
DOI: 10.1038/s41598-022-06109-7
PMCID: PMC8826857

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