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Loss of the <i>PPE71-esxX-esxY-PPE38</i> locus drives adaptive transcriptional responses and hypervirulence of <i>Mycobacterium tuberculosis</i> Lineage 2

2025-04-16

Abstract excerpt

Mycobacterium tuberculosis ( M.tb ) is remarkable for its immense global disease burden and low mutation rate. Despite strong selective pressure, M.tb shows frequent deletions at the PPE71–38 locus, most notably in hypervirulent L2 Beijing strains. Here, we show that loss of the PPE71– 38 locus causes increased stress response gene expression and increased triglyceride levels. In addition, we demonstrate that...

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Literature Corpus work
a2fa4ea7-36c4-59fc-8a46-9a28c0d7223f
DOI
10.1101/2025.04.16.649112
Open publication

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Loss of the <i>PPE71-esxX-esxY-PPE38</i> locus drives adaptive transcriptional responses and hypervirulence of <i>Mycobacterium tuberculosis</i> Lineage 2DOI 10.1101/2025.04.16.649112
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