Article

Antibody responses against bacterial glycans affinity mature and diversify in germinal centers

2025-03-31

Abstract excerpt

<h4>Summary</h4> Anti-carbohydrate antibodies (Abs) play crucial roles in pathogen control, but their generation remains poorly understood. By studying responses to Streptococcus pyogenes in humans, we reveal that the glycan-targeted response shifts from IgM towards IgG and IgA memory with age and antigen exposure across blood, spleen, and tonsils. Both natural colonization and controlled human infection with S...

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Literature Corpus work: 42386f1a-cbcf-544e-b119-d44477a0ef83
DOI: 10.1101/2025.03.26.645614

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