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Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals

1 Jul 2017

Abstract excerpt

Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM + plasma cells (PCs) were more abundant in humans than mice and clonally related to a large repertoire of memory IgM + B cells disseminated throughout the intestine but rare in systemic lymphoid organs. In addition to sharing a gut-specific gene signature with memory IgA + B cells,...

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Clostridium difficile and Clostridium perfringens research
Gut microbiota and health
Immune Cell Function and Interaction

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28709802
DOI: 10.1016/j.immuni.2017.06.013

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