Article
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype.
Mucosal immunology - 1 Jun 2023
Ramonell Richard P, Brown Margaret, Woodruff Matthew C, Levy Joshua M, Wise Sarah K, DelGaudio John, Duan Meixue, Saney Celia L, Kyu Shuya, Cashman Kevin S, Hom Jennifer R, Fucile Christopher F, Rosenberg Alexander F, Tipton Christopher M, Sanz Ignacio, Gibson Gregory C, Lee F Eun-Hyung
Abstract excerpt
Immunoglobulin (Ig) E is central to the pathogenesis of allergic conditions, including allergic fungal rhinosinusitis. However, little is known about IgE antibody secreting cells (ASCs). We performed single-cell RNA sequencing from cluster of differentiation (CD)19+ and CD19- ASCs of nasal polyps from patients with allergic fungal rhinosinusitis (n = 3). Nasal polyps were highly enriched in CD19+ ASCs....
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