Article
Teleost IgD+IgM- B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles.
Cell reports - 24 Dec 2019
Perdiguero Pedro, Martín-Martín Alba, Benedicenti Ottavia, Díaz-Rosales Patricia, Morel Esther, Muñoz-Atienza Estefanía, García-Flores Mónica, Simón Rocío, Soleto Irene, Cerutti Andrea, Tafalla Carolina
Abstract excerpt
Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD+IgM- plasmablasts constitute a major lymphocyte population in some mucosal surfaces, including the gut mucosa. Remarkably, secreted IgD binds to gut commensal bacteria, which in turn stimulate IgD gene transcription in...
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