Article
TRPV5: a Ca(2+) channel for the fine-tuning of Ca(2+) reabsorption.
Handbook of experimental pharmacology - 1 Jan 2014
Na Tao, Peng Ji-Bin
Abstract excerpt
TRPV5 is one of the two channels in the TRPV family that exhibit high selectivity to Ca(2+) ions. TRPV5 mediates Ca(2+) influx into cells as the first step to transport Ca(2+) across epithelia. The specialized distribution in the distal tubule of the kidney positions TRPV5 as a key player in Ca(2+) reabsorption. The responsiveness in expression and/or activity of TRPV5 to hormones such as 1,25-dihydroxyvitamin...
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