Modeling the structural and dynamical changes of the epithelial calcium channel TRPV5 caused by the A563T variation based on the structure of TRPV6.

doi:10.1080/07391102.2018.1518790

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Article

Modeling the structural and dynamical changes of the epithelial calcium channel TRPV5 caused by the A563T variation based on the structure of TRPV6.

Journal of biomolecular structure & dynamics - 1 Aug 2019

Wang Lingyun, Holmes Ross P, Peng Ji-Bin

Abstract excerpt

TRPV5, transient receptor potential cation channel vanilloid subfamily member 5, is an epithelial Ca2+ channel that plays a key role in the active Ca2+ reabsorption process in the kidney. A single nucleotide polymorphism (SNP) rs4252499 in the TRPV5 gene results in an A563T variation in the sixth transmembrane (TM) domain of TRPV5. Our previous study indicated that this variation increases the Ca2+ transport...

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PMID: 30175942
DOI: 10.1080/07391102.2018.1518790
PMCID: PMC6397782

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