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Article

An E-cadherin endocytic mutant rescues the severe epidermal p120-catenin null phenotype.

Molecular biology of the cell - 1 Jun 2026

Schell Stephanie L, Seo Tadahiko, Xu Haifang, Sennett Mackenzie L, Ding Kevin, Helm Matthew F, Lanza Matthew, Nelson Amanda M, Kowalczyk Andrew P

Abstract excerpt

Cadherins are linked to actin through α- and β -catenin. p120 catenin (p120) also binds to the cadherin cytoplasmic domain and prevents cadherin endocytosis. In mouse epidermis, p120 gene ablation leads to severe skin inflammation and early postnatal lethality. These outcomes have been ascribed to cadherin-independent functions of p120 in RhoA and NFκB inflammatory signaling. However, the downregulation of...

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Identifiers

PMID: 42024491
DOI: 10.1091/mbc.E26-01-0040
PMCID: PMC13229123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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