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E‐cadherin's role in development, tissue homeostasis and disease: Insights from mouse models

2 Dec 2014

Abstract excerpt

Recent studies uncovered critical roles of the adhesion protein E-cadherin in health and disease. Global inactivation of Cdh1, the gene encoding E-cadherin in mice, results in early embryonic lethality due to an inability to form the trophectodermal epithelium. To unravel E-cadherin's functions beyond development, numerous mouse lines with tissue-specific disruption of Cdh1 have been generated. The consequences...

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PMID: 25449798
DOI: 10.1002/bies.201400141

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