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Article

Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier

31 Dec 2007

Abstract excerpt

The cornified envelope is assembled from transglutaminase cross-linked proteins and lipids in the outermost epidermal layers and is essential for skin barrier function. Involucrin, envoplakin, and periplakin form the protein scaffold on which the envelope assembles. To examine their combined function, we generated mice deficient in all three genes. The triple knockouts have delayed embryonic barrier formation and...

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Identifiers

PMID: 18166659
DOI: 10.1083/jcb.200706187

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